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Active research projects

Our research team is always looking for ways to improve the health of children. There are several clinical trials that are currently under way.

Active research projects

Project Title

Principle Investigator

Pediatric thyroidectomy: a single institution series Black
Incidence and Variety of Infection During Remission Induction Therapy of Acute Lymphocytic Leukemia (ALL) Bowman
Evaluation of Cardiac Toxicity in Patients who Received Low Dose Anthracyclines for Treatment of Cancer in Childhood Bowman
Efficacy of Cognitive Remediation for Attention Deficits Secondary to Treatment for Acute Lymphoblastic Leukemia or Brain Tumor in Children: A Pilot Study Colaluca
Irinotecan and Vincristine for Radiosensitization of I-MIBG Therapy in Resistant/Relapsed High-Risk Neuroblastoma (N04-06) Granger
The Effect of Nurse Staffing on Select Identified Patient Outcomes in the Pediatric Intensive Care Unit (PICU): A Pilot Study Layman
Reduce PICU Discharge Delays and Improve Patient flow Petersen
The Incidence of Serious Bacterial Infection in Infants with Respiratory Syncytial Virus and Respiratory Failure Thompson
Osteosarcoma: Outcome of Therapy Based on Histologic Response Akers
Treatment of Patients with Newly Diagnosed Acute Myeloid Leukemia or Myelodysplasia (AML02): A Collaborative Trial of St. Jude Children's Hospital, Stanford University Medical Center, Cook Children's Medical Center and Children's Hospital of Michigan Bowman
Total Therapy Study XV for Newly Diagnosed Patients with Acute Lymphoblastic Leukemia Bowman
(DISCOVER) CFTR potentiator VX770 in CF patients homozygous for ?F508 Cunningham
Data Collection for the International Bone Marrow Transplant Registry Eames
A Data Collection Protocol for Recipients of Allogenic Unrelated Umbilical Cord Blood through the National Marrow Donor Program Eames
Data Collection for the National Marrow Donor Program Eames
Soluble Tumor Necrosis Factor Receptor: Enbrel® (Etanercept) for the Treatment of Acute Non-Infectious Pulmonary Dysfunction (Idiopathic Pneumonia Syndrome) Following Allogeneic Stem Cell Transplantation ASCT0521 Eames
National Wilms' Tumor Study-5: Therapeutic Trial and Biology Study-POG 9440 Granger
Hepatoblastoma Biology and Tissue Bank-POG 9346 Granger
Primary Surgical Therapy for Biologically Defined Low-Risk Neuroblastoma, Inter Group Study-POG 9641 Granger
A Phase II Study of ABT-751, an Orally Bioavailable Tubulin Binding Agent, in Children with Relapsed or Refractory Neuroblastoma ANBL0621 Granger
A Phase III Trial of High Dose Interferon Alpha-2b Versus Cisplatin, Vinblastine, DTIC Plus IL-2 and Interferon in Patients with High Risk Melanoma COGS0008 Granger
A Phase III Randomized Trial of Gemtuzumab Ozogamicin (Mylotarg) Combined with Conventional Chemotherapy for De Novo Acute Myeloid Leukemia in Children, Adolescents and Young Adults AAML0531 Granger
Response and Biology-Based Therapy for Intermediate-Risk Neuroblastoma ANBL0531 Granger
A Group-wide, Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy ACCL05C1 Granger
Feasibility and Dose Discovery Analysis of Zoledronic Acid with Concurrent Chemotherapy in the Treatment of Newly Diagnosed Metastatic Osteosarcoma AOST06P1 Granger
131I-Metaiodobenzylguanidine (MIBG) with Intensive Chemotherapy and Autologous Stem Cell Rescue for High-Risk Neuroblastoma IND# 76,227, Draximage® (N01-02) Granger
A Randomized Trial of Sirolimus-Based Graft versus Host Disease Prophylaxis after Hematopoietic Stem Cell Transplantation in Selected Patients with CR1 and CR2 ALL Granger
ADVL0821, Phase II Study of IMC-A12 (Anti-IGF-I Receptor Monoclonal Antibody IND# 100947, NCS# 742460) in Children with Relapsed /Refractory Solid Tumors Granger
Intergroup Protocol for Treatment of Children with Hepatoblastoma-POG 9645 Granger
Randomized Study of Vincristine, Actinomycin-D, and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine, Topotecan and Cyclophosphamide for Patients with Intermediate Risk Rhabdosarcoma-POGD9803 Granger
AlinC 17 Treatment for Patients with Low Risk ALL-POG 9904 Granger
AlinC 17 Treatment for Patients with Standard Risk ALL-POG 9905 Granger
A5971, A Randomized, Phase III Study for the Treatment of Newly Diagnosed Disseminated Lymphoblastic Lymphoma or Localized Lymphoblastic Lymphoma Granger
A2971 Treatment of Children with Down Syndrome (DS) and Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS), and Transient Myeloproliferative Disorder (TMD) Granger
Chemotherapy for Progressive Low Grade Astrocytoma in Children Less Than 10 Years of Age-POG A9952 Granger
Systemic Chemotherapy, Second Look Surgery and Conformal Radiation Therapy Limited to the Posterior Fossa and Primary Site for Children > 8 months and < 3 years with Non-metastatic Medulloblastoma-POG P9934 Granger
AlinC 17: Protocol for Patients with Newly Diagnosed High Risk ALL POG 9906 Granger
ALINC17:Laboratory Classification/Cytogenics Protocol for Acute Lymphocytic Leukemia-A Non-Therapeutic POG Study #9900/9907 Granger
A Randomized Study of Purged vs. Unpurged Peripheral Blood Stem Cell Transplant Following Dose Intensive Induction Therapy for High Risk Neuroblastoma COG A3973 Granger
Trial of Chemotherapy Intensification through Interval Compression in Ewing Sarcoma and Related Tumors (AEWS0031) Granger
A Pilot Study of Re-induction Chemotherapy with Ifosamide, and Vinorelbine (IV) in Children with Refractory/Relapsed Hodgkin Disease AHOD00P1 Granger
ARST0121, A Groupwide, Randomized, Phase II Window Study of Two Different Schedules of Irinotecan in Combination with Vincristine and Pilot Assessment of Safety and Efficacy of Tirapazamine Combined with Multiagent Chemotherapy for First Relapse or Progressive Disease in Rhabdomyosarcoma and Related Tumors Granger
A Phase III, Group-Wide Study of Dose-Intensive Response-Based Chemotherapy and Radiation Therapy for Children and Adolescents with Newly Diagnosed Intermediate Risk Hodgkin Disease-AHOD0031 Granger
A Children's Oncology Group Pilot Study for the Treatment of Very High Risk Acute Lymphoblastic Leukemia in Children & Adolescents-AAL0031 Granger
Intensive Induction Therapy for Children with Acute Lymphoblastic Leukemia (ALL) who Experience a Bone Marrow Relapse AALL01P2 Granger
A Phase II Study of Gleevec in PH+ Chronic Phase Myelogenous Leukemia - AAML0123 Granger
AEWSO2B1: A Groupwide Biology and Banking Study for Ewing Sarcoma Granger
A Phase III Study of Reduced Therapy in the Treatment of Children with Low and Intermediate Risk Extracranial Germ Cell Tumors - AGCT0132 Granger
A Phase III Trial of Treatment of Advanced-Stage Anaplastic Large Cell Lymphoma (ALCL) with Standard APO (Doxorubicin, Prednisone, Vincristine) versus Consolidation with a Regimen Including Vinblastine ANHLO131 Granger
Osteosarcoma Biology Protocol:Companion to Group Wide Therapeutic Studies COG P9851 Granger
A Phase II Study of Weekly Gemcitabine and Vinorelbine in Children with Recurrent or Refractory Hodgkin Disease AHOD0321 Granger
Vincristine, Dactinomycin and Lower Doses of Cyclophosphamide with or without Radiation Therapy for Patients with Newly Diagnosed Low-Risk Embryonal/Botryoid/Spindle Cell Rhabdomyosarcoma ARST0331 Granger
A Pilot Study to Determine the Toxicity of the Addition of Rituximab to the Induction and Consolidation Phases and the Addition of Rasburicase to the Reduction Phase in Children with Newly Diagnosed Advanced B-Cell Leukemia/Lymphoma Treated with LMB/FAB Therapy (ANHL01P1) Granger
A Phase II Study of hu14.18-IL2* (BB-IND-9798) in Children with Recurrent or Refractory Neuroblastoma ANBL0322 Granger
A Pilot Study of Low-Dose Antiangiogenic Chemotherapy in Combination with Standard Multi-agent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma Family of Tumors AEWS02P1 Granger
A Phase II Study of Aerosolized GM-CSF (NSC# 613795, IND#11042) in Patients with First Pulmonary Recurrence of Osteosarcoma AOST0221 Granger
A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy ARET0332 Granger
Perinatal Neuroblastoma: Expectant Observation ANBL00P2 Granger
Intensive Multi-Agent Therapy, Including Dose-Compressed Cycles of Ifosfamide/Etoposide (IE) & Vincristine/Doxorubicin/Cyclophosphamide (VDC) for Patients with High-Risk Rhabdomyosarcoma ARST0431 Granger
Induction Intensification and Allogeneic Bone Marrow Transplant in Infant ALL: A POG Pilot Study-POG P9407 Granger
Pharmacology and Toxicity of Erwinia Asparaginase (Erwinase; Crisantaspase; IND 290) Following Allergy to PEG-asparaginase in Treatment of Children with Acute Lymphoblastic Leukemia (ALL) AALL07P2 Heym
Management of mediastinal masses: a quality improvement and research initiative Heym
The Use of Modified BFM+/- Compound 506U78 (NSC# 686673) in an Intensive Chemotherapy Regimen for Treatment of T-Cell Leukemia AALL00P2 Heym
Classification of Acute Lymphoblastic Leukemia AALL03B1 Heym
A Phase III Study for the Treatment of Children and Adolescents with Newly Diagnosed Low Risk Hodgkin Disease (AHOD0431) Heym
(CASG 106 Pleconaril) A Double-Blind, Placebo-Controlled, Virologic Efficacy Trial of Pleconaril (VP-63843) in the Treatment of Neonates with Enteroviral Sepsis Syndrome (CASG106 DMID #99-018, Protocol Version 5.0 dated 07 April 2006) Murphey
A Phase II Trial of Conformal Radiation Therapy for Pediatric Patients with Localized Ependymoma, Chemotherapy Prior to Second Surgery for Incompletely Resected Ependymoma and Observation for Completely Resected, Differentiated, Supratentorial Ependymoma Murray
A Phase II Study to Assess the Ability of Neoadjuvant Chemotherapy +/- Second Look Surgery to Eliminate All Measurable Disease Prior to Radiotherapy for NGGCT (ACNS0122) Murray
Concurrent Radiation and Temozolomide and Lomustine in the Treatment of High-Grade Gliomas - ACNS0423 Murray
A Pilot Study Using Carboplatin, Vincristine and Temozolomide for Children < 10 Years with Progressive/Symptomatic Low-Grade Gliomas (ACNS0223) Murray
A Phase II Study of Conformal Radiotherapy in Patients with Low-Grade Gliomas (ACNS0221) Murray
Intravitreal Bevacizumab (Avastin) Injections Versus Conventional Laser Surgery for Vision-Threatening Retinopathy of Prematurity: A Prospective, Randomized, Non-Blinded, Controlled, Multi-Center, Clinical Trial Riley
The Universal Data and Serum Specimen Collection System for Hemophilia Sanders
Rituximab for the Treatment of Inhibitors in Congenital Hemophilia A – The RICH Study Torres
(PO2538 LTFU) Assessment of the Safety, Efficacy, Tolerability and Pharmacokinetics of PEG-Intron Plus Rebetol in Pediatric with Chronic Hepatitis C (Amendment #2-Long Term Follow up study) Whitworth
(CASG 112) A Phase III Randomized, Placebo-Controlled Blinded Investigation of Six Week vs. Six Months of Oral Valganciclovir Therapy in Infants with Symptomatic Congenital Cytomegalovirus Infection (CASG112, DMID 06-0046, Protocol Version 5.0, dated 9 Dec 2010) Whitworth
The EPIC Observational Study: Longitudinal Assessment of Risk-Factors For and Impact of Pseudomonas Aeruginosa Acquisition and Early Anti-Pseudomonal Treatment in Children with Cystic Fibrosis Dyson
Unrelated Donor Reduced Intensity Bone Marrow Transplant for Children with Severe Sickle Cell Disease BMT CTN 0601 Eames
A Phase I Study of Intravenous (Emulsion) Fenretinide (4-HPR, NSC 374551) in Children with Recurrent or Resistant Neuroblastoma (IND #70,058) (N04-03) Granger
A Comprehensive Safety Trial of Chimeric Antibody 14.18 (ch14.18) with GM-CSF, IL-2 and Isotretinoin in High-Risk Neuroblastoma Patients Following Myeloablative Therapy

Granger
A Randomized Phase II Trial of Bevacizumab (IND# 7921, Avastin) and Temsirolimus (IND# 61010, Torisel) in Combination with Intravenous Vinorelbine and Cyclophosphamide in Patients with Recurrent/Refractory Rhabdomyosarcoma Granger
A Phase II Study of Sulindac and Tamoxifen in Patients with Desmoid Tumors that are Recurrent or Not Amendable to Standard Therapy ARST0321 Granger
A Randomized Trial of the European and American Osteosarcoma Study Group to Optimize Treatment Strategies for Resectable Osteosarcoma Based on Histological Response to Pre-Operative Chemotherapy (AOST0331) Granger
(OL 1004) Safety and Effectiveness of Open-Label Clobazam in Subjects with Lennox-Gastaut Syndrome (OV-1004) Hernandez-Mulero
AAML0523, A Phase I/II Study of CLOLAR® (Clofarabine, IND# 73,789) in Combination with Cytarabine in Pediatric Patients with Refractory/Relapsed Leukemia Heym
High Risk B-Precursor Acute Lymphoblastic Leukemia - AALL0232 Heym
(SUPPORT) Services Uniting Pediatric & Psychiatry Outreaching to Texas Levy
Fluconazole Prophylaxis for the prevention of Candidiasis in Infants < 750 Grams Birth Weight Nedrelow
(ISS) A Four-Year Open-Label Multi-Center Randomized Two-Arm Study of Genotropin in Idiopathic Short Stature Patients: Comparing an Individualized, Target-Driven Treatment Regimen to Standard Dosing of Genotrophin Thornton
Readiness of Cook Children's Nurses for Evidence Based Practice
The National Initiative for Families with Duchenne
Evaluation of immunization status of pediatric patients upon hospital admission and after discharge Ajanaku
(Sperm Banking project) St Jude Sperm Banking project - SBANK10: Sperm Banking Among Adolescents Newly Diagnosed with Cancer: Development of a Profiling and Referral Tool Albritton
Exploring the History of Adolescent and Young Adult Cancer Patients, and Setting New Benchmarks for Future Care: The Cook Children's Experience Albritton
Risk Factors for Maladaptation in Siblings of Pediatric Oncology Patients Bailey
Evaluation of the Utility of a Transition Workbook in Preparing Adolescent and Young Adult Cancer Survivors (AYACS) for Transition to Adult Services: A Pilot Study Bashore
The Epidemiology of Diamond Blackfan: The Diamond Blackfan Anemia Registry Beam
Inhibitor Development in Previously Untreated Patients (PUPs) or Minimally Blood Component-Treated Patients (MBCTPs) when Exposed to Plasma-Derived von Willebrand Factor-Containing Factor VIII (VWF/FVIII) Concentrates and to Recombinant Factor VIII (rFVIII) Concentrates: An Independent, International, Multicentre, Prospective, Controlled, Randomised, Open Label, Clinical Trial (SIPPET--Survey of Inhibitors in Plasma-Product Exposed Toddlers) Beam
Severe Chronic Neutropenia International Registry Protocol Beam
Patient Care Evaluation Study of Institutional Acute Lymphoblastic Leukemia (ALL) Relapse Bowman
Erwinia chrysanthemi L-asparaginase for Injection IND 290 Bowman
Childhood Cancer Survivor Study Bowman
A Retrospective Chart Analysis of Survival Rate and Treatment-related Mortality Following Post Myeloablative Stem Cell/Bone Marrow Transplant in Pediatric Acute Lymphoblastic Leukemia Bowman
Pilot Study of the Genetic Epidemiology of Childhood Cancer Bowman
Incidence of Cancer among Infants at Cook Children's Medical Center. Bowman
H-26831, Passport For Care: Texas Implementation – Survivor Consent Bowman
The Occurrence and Distribution of Second Malignancy Following Initial Diagnosis and Treatment of Childhood Cancer at Cook Children's Medical Center: Implications for Survivorship and Long-term Follow-up Bowman
Donation after Cardiac Death Experience in a Large Tertiary Care Pediatric Hospital Caballero
CHEX Critical Care Blended Learning Orientation Model Chapa
Yield of a routine screening protocol for siblings and contacts of children evaluated for physical abuse. Coffman
A Study of Neurocognitive Function in Children Treated for ALL AALL06N1 Colaluca
Participation in the Cystic Fibrosis Patient Registry Cunningham
(Twin/Sibling) Genetic Modifiers of Cystic Fibrosis Cunningham
Vagus Nerve Stimulator Placement in the Pediatric Patient Donahue
Diagnoses and outcomes in temporal lobectomies in children: assessing the utility and disutility of iMRI and en bloc hippocampal resection Donahue
Blood Collection for National Marrow Donor Program Eames
Multi-Center, Open-label, Randomized Trial Comparing Single Versus Double Umbilical Cord Blood (UCB) Transplantation in Pediatric Patients with High Risk Leukemia and Myelodysplasia BMT CTN 0501 Eames
(COG BMT CTN 0801) A Phase II/III Randomized, Multicenter Trial Comparing Sirolimus plus PDN and Sirolimus/Calcineurin Inhibitor plus PDN for the Treatment of Chronic Graft-versus-Host Disease. Eames
10-CBA, A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications Eames
Protocol for a Research Database for Hematopoietic Stem Cell Transplantation and Marrow Toxic Injuries Eames
BMT-CTN0301: Fludarabine-based Conditioning for Allogeneic Marrow Transplantation from HLA-compatible Unrelated Donors in Severe Aplastic Anemia Eames
(DAP-PEDS) An Evaluation of the Safety, Efficacy and Pharmacokinetics of Daptomycin in Pediatric Subjects Aged Two to Seventeen Years with Complicated Skin and Skin Structure Infections Caused by Gram-Positive Pathogens Eger


DAP-PEDS-09-01: An Evaluation of the Pharmacokinetic Profile and Safety of a Single Dose of Daptomycin in Pediatric Subjects Aged Three Months to Twenty-Four Months Who are Concurrently Receiving Standard Antibiotic Therapy for Proven or Suspected Bacterial Infection Including Peri-Operative Prophylactic Use of Antibiotics
Eger
TTF-1 Expression in Wilms Tumor Galliani
Patient Care Evaluation Study of Institutional Kidney Tumors Galliani
A Randomized, Double-Blind, Controlled Trial of Cycling Continuous Sedative Infusions in Critically Ill Pediatric Patients Requiring Mechanical Ventilation Gelvez
LSD Registry Gillespie
Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS) ARST0531 Granger
Hodgkins Disease (HD) Banking Study AHOD04B1 Granger
Treatment of Newly Diagnosed Higher Risk Favorable Histology Wilms Tumors AREN0533 Granger
The Treatment of Down Syndrome Children with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) under the Age of 4 Years AAML0431 Granger
An Open-Label Treatment Protocol for the Use of Voraxaze as Adjunctive Treatment for Patients Experiencing or at Risk of Methotrexate Toxicity (PR001-CLN-pro16) Granger
Risk-Based Treatment for Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) ARST0332 Granger
Phase III Randomized Trial of Single vs. Tandem Myeloablative Consolidation Therapy for High-Risk Neuroblastoma ANBL0532 Granger
Protocol for the Enrollment on the Official COG Registry, The Childhood Cancer Research Network ACCRN07 Granger
A Trial of Intensive Multi-Modality Therapy for Extra-Ocular Retinoblastoma ARET0321 Granger
A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens AOST06B1 Granger
A COG Study for Collecting and Banking Ewing Sarcoma Specimens AEWS07B1 Granger
Glutamic Acid to Decrease Vincristine Toxicity in Children with Cancer ACCL0731 Granger
Defibrotide for Patients with Hepatic Veno-Occlusive Disease (VOD): A Treatment IND Study (Under CFR 312.34) Granger
Neuropsychological, Social, Emotional and Behavioral Outcomes in Children with Cancer Granger
Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Stem Cell Transplantation (SCT) for Refractory and Relapsed Acute Myelogenous Leukemia (AML) and Newly Diagnosed AML with Monosomy 7 or -5/5q- in Children: A Children's Oncology Group (COG) Study AAML05P1 Granger
(NANT 07 02) A Phase I Study of Bevacizumab with Bolus and Metronomic Cyclophosphamide and Zoledronic Acid in Children with Recurrent or Refractory Neuroblastoma (N07-02) Granger
Phase I Study of Fenretinide (4-HPR, NSC 374551) Lym-X-Sorb (LXS) Oral Powder in Patients with Recurrent or Resistant Neuroblastoma NANT 2004-04 (N04-04) Granger
Carcinogen Metabolism, DNA Repair, Parental Exposures, and Retinoblastoma AEPI05N1 Granger
Modulation of Intensive Melphalan (L-PAM) by Buthionine Sulfoximine (BSO) with Autologous Stem Cell Support for Resistant/Recurrent High-Risk Neuroblastoma NANT (N99-02) Granger
Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor AREN0534 Granger
Vorinostat With 131I-MIBG Therapy for Resistant/Relapsed Neuroblastoma: A Phase 1 Study (IND# 105, 744)(N07-03) Granger
A Pilot Study to Evaluate Novel Agents (Temozolomide and Cixutumumab [IMC-A12, Anti-IGF-IR Monoclonal Antibody, IND #100947, NSC #742460]) in Combination with Intensive Multi-Agent Interval Compressed Therapy for Patients with High-Risk Rhabdomyosarcoma ARST08P1 Granger
AHEP0731, Treatment of Children with All Stages of Hepatoblastoma Granger
A Retrospective Review of the Pharmacoeconomics and Outcomes of Relapsed Therapy (PORT) in Pediatric Patients with Neuroblastoma, Rhabdomyosarcoma, and Ewing Sarcoma Granger
ALTE05N1, Umbrella Long-Term Follow-up Protocol Granger
Phase I study of vorinostat in combination with 13-cis-retinoic acid in patients with refractory/recurrent neuroblastoma. Granger
AEWS1031, A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma Granger
NEUROBLASTOMA BIOLOGY STUDY Granger
ADVL0921, A Phase II Study of MLN8237 (IND# 102984), a Selective Aurora A Kinase Inhibitor in Children with Recurrent/Refractory Solid Tumors and Leukemias Granger
Treatment of Adrenocortical Tumors with Surgery plus Lymph Node Dissection and Multiagent Chemotherapy Granger
A COG Soft Tissue Sarcoma Diagnosis, Biology and Banking Protocol D9902 Granger
Neuroblastoma Biology Studies (ANBL00B1) Granger
ANBL0032-Phase III Randomized Study of Chimeric Antibody 14.18 (Ch14.18) in High Risk Neuroblastoma Following Myeloablative Therapy and Autologous Stem Cell Rescue Granger
International Pediatric Adrenocortical Tumor Registry (IPACTR) Data Collection and Use of Tissue for Banking and Research Granger
AEWS0331, European Ewing Tumor Working Initiative of National Groups Ewing Tumor Studies 1999 Granger
A Phase III, Randomized Trial of Intravenous Gammaglobulin Therapy for Patients with Neuroblastoma Associated Opsoclonus-Myoclonus-Ataxia Syndrome Treated with Chemotherapy and Prednisone - ANBL00P3 Granger
COG-LTFI: A Groupwide Protocol for Collecting Follow-Up Data for ALL (Including IRB file numbers 261(POG 9904), 262(POG 9905), 304(POG 9906) 307(POG 9900/9907)& 397 (AALL0031) Granger
COG-LTFI: A Groupwide Protocol for Collecting Follow-Up Data for Lymphoma and B-Cell ALL (Including IRB file numbers: 284 (A5971) Granger
COG-LTFI: A Groupwide Protocol for Collecting Follow-Up Data for CNS/Brain Tumors (Including IRB file numbers 293 (POG A9952), 298 (COG P9934) Granger
COG-LTFI: A Groupwide Protocol for Collecting Follow-Up Data for Neuroblastoma (Including: IRB file numbers 156 (POG 9641), 315 (A3973) Granger
A Groupwide Protocol for Collecting Follow-Up Data for AML (Including IRB file numbers 286 (A2971) & 409 (AAML0123) Granger
A Groupwide Protocol for Collecting Follow-Up Data for Hodgkin's Disease (Including IRB file numbers 329 (AHOD00P1), 478 (AHOD0321) Granger
A Groupwide Protocol for Collecting Follow-Up Data for Rhabdomyosarcoma (Including file numbers 226 (POGD9602) Granger
A Groupwide Protocol for Collecting Follow-Up Data for Wilm's Tumor (Including IRB file number 122 (POG 9440) Granger
COG Study ALTE03N1: Key Adverse Events after Childhood Cancer Granger
A Groupwide Protocol for Collecting Follow-Up Data for Ewing's Sarcoma (Including IRB file number 326 (AEWS0031) Granger
ANHL04B1 - Rare and Cutaneous Non-Hodgkin Lymphoma Registry Granger
Renal Tumors Classification, Biology, And Banking Study (AREN03B2) Granger
A Children's Oncology Group Protocol for Collecting and Banking Pediatric Research Specimens Including Rare Pediatric Tumors ABTR01B1 Granger
Treatment of High Risk Renal Tumors AREN0321 Granger
Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy ARAR0331 Granger
Treatment for Very Low and Standard Risk Favorable Histology Wilms Tumor AREN0532 Granger
Humanitarian Device Exemption (H030009)-Vertical Expandable Prosthetic Titanium Rib (VEPTR) Gray
Orthopedic Spine Disorders Registry

Gray
LittlEARS Auditory QUESTIONNAIRE & FIRST WORDS LIST: Children with MED-EL Cochlear Implant System; LANGUAGE NORTH AMERICAN ENGLISH Haggerty
Amantadine in the treatment of intractable absence epilepsy Hernandez-Mulero
Hydrocephalus Post-Hemispherectomy Hernandez-Mulero
An Investigation of the Prevalence and Incidence of Patients with Non-Epileptic Seizures and Duration of Epileptic Seizures in the Epilepsy Monitoring Unit Hernandez-Mulero
Childhood Absence Epilepsy Rx, PK-PD Pharmacogenetics Hernandez-Mulero
Intensified Methotrexate, Nelarabine and Augmented BFM Therapy for Children and Young Adults with Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia - AALL0434 Heym
A Children's Oncology Group Protocol for Collecting and Banking Relapsed Acute Lymphoblastic Leukemia Research Specimens AALL05B1 Heym
Intensive Treatment for Intermediate-Risk Relapse of Childhood B-Precursor Acute Lymphoblastic Leukemia (ALL): A Randomized Trial of Vincristine Strategies AALL0433 Heym
A Phase III Study Risk Directed Therapy for Infants with Acute Lymphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +/- FLT3 Inhibition (CEP-701, Lestaurtinib; IND #76431; NSC # 671807) AALL0631 Heym
Intensified Tyrosine Kinase Inhibitor Therapy in Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia AALL0622 Heym
AML08: A Phase III Randomized Trial of Clofarabine Plus Cytarabine versus Conventional Induction Therapy and a Phase II Study of Natural Killer Cell Transplantation in Patients with Newly Diagnosed Acute Myeloid Leukemia Heym
Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS) Heym
AALL07P1,A Phase II Pilot Trial of Bortezomib (PS-341, Velcade, IND#58,4430 in Combination with Intensive Re-Induction Therapy for Children with Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL) Heym
A Non-Randomized Phase III Study of Response Adapted Therapy for the Treatment of Children with Newly Diagnosed High Risk Hodgkin Lymphoma AHOD0831 Heym
TBANK, Protocol for Collecting, Banking and Distributing Human Tissue Samples: St. Jude Children's Research Hospital Tissue Resources Core Facility Heym
MTP-OS-403, Liposomal Muramyl Tripeptide Phosphatidyl Ethanolamine (L-MTP-PE): Compassionate Access for High Risk Osteosarcoma Heym
AALL08B1, Classification of Newly Diagnosed Acute Lymphoblastic Leukemia (ALL) Heym
AALL0932, Treatment of Patients with Newly Diagnosed Standard Risk B-Precursor Acute Lymphoblastic Leukemia (ALL) Heym
Risk Adapted Treatment of Newly Diagnosed Childhood Acute Promyelocytic Leukemia (APL) using Arsenic Trioxide (Trisenox® IND# 103,331) during Consolidation Heym
AAML07P1, A Phase II Pilot Study of Bortezomib (PS-341, Velcade, IND# 58,443) Combined with Reinduction Chemotherapy in Children and Young Adults with Recurrent, Refractory or Secondary Acute Myeloid Leukemia Heym
MTP-OS-403, Liposomal Muramyl Tripeptide Phosphatidyl Ethanolamine

(L-MTP-PE): Compassionate Access for High-risk Osteosarcoma
Heym
Standard Risk B-Precursor Acute Lymphoblastic Leukemia: A Phase III Group Wide Study AALL0331 Heym
The Effect of a Single Family Room NICU Environment on Parental and Staff Stress Hoff
Endoscopic Craniosynostosis Surgery Honeycutt
Pediatric Deep Brain Stimulation Honeycutt
Surgery in an iMRI Honeycutt
Identification of New Mechanistic Biomarkers of Adverse Responses to Acetaminophen Honeycutt
An Evaluation of the Benefits of iMRI vs. non-iMRI in the Surgical Resection of Intracranial Tumors Honeycutt
Identification of Factors Related to Burnout and "Compassion Fatigue" in

Pediatric Healthcare Workers and the Impact of a Stress Hardiness Program

Hood
01-0923, A Study of Hematopoietic Stem Cell Transplantation (HSCT) in Non-Malignant Disease Using a Reduced-Intensity Preparatory Regime with Campath-1H, Fludarabine and Melphalan Howrey
(Retina Eval w/ IICP) Retinal Evaluation in Patients with Increased Intracranial Pressure Hunt
(PFAST: Patent Foramen Ovale & Stroke) PFAST: Patent Foramen Ovale & Stroke Johnson
IRB Test Study Keane
Multi-institutional Analysis of Factors Associated with Unplanned Extubations (UPE) in Pediatric Intensive Care Units Layman
Functional Recovery from Posterior Fossa Syndrome: Comparison of Malignant versus Benign Tumors: Retrospective Analysis Marks
(Lower limb spastic CP (Botulinum Toxin)) Project 52120 Protocol Y-55-52120-141 A PHASE III, MULTICENTRE, DOUBLE BLIND, PROSPECTIVE , RANDOMISED, PLACEBO CONTROLLED STUDY ASSESSING THE EFFICACY AND SAFETY OF DYSPORT® USED IN THE TREATMENT OF LOWER LIMB SPASTICITY IN CHILDREN WITH DYNAMIC EQUINUS FOOT DEFORMITY DUE TO CEREBRAL PALSY. Dysport- Botulinum Toxin - Pediatric Lower Limb Spasticity Study Marks
(OL Spasticity study - Y 55 52120 147) A PHASE III, PROSPECTIVE, MULTICENTRE, OPEN LABEL, EXTENSION STUDY ASSESSING THE LONG TERM SAFETY AND EFFICACY OF REPEATED TREATMENT WITH DYSPORT USED IN THE TREATMENT OF LOWER LIMB SPASTICITY IN CHILDREN WITH DYNAMIC EQUINUS FOOT DEFORMITY DUE TO CEREBRAL PALSY Marks
Evaluation of Explantation of Intrathecal Baclofen Pumps in Pediatric Patients Marks
Activa® Dystonia Therapy Marks
P903-21 Pharmacokinetics of a Single Dose of Ceftaroline fosamil in Children Ages Birth to Younger Than 12 Years With Suspected or Confirmed Infection Marshall
Effects of therapeutic suggestion during light anesthesia on outcomes and implicit memory in children post tonsillectomy. Martin
Molecular Characterization of Immune Receptors and Gene-Specific Hypermethylation in Hispanic, Caucasian and African American Children with Acute Lymphoblastic Leukemia (ALL) Mathew
A Prospective, Open Label Study to Assess the Pharmacokinetics, Safety & Efficacy of Anidulafungin when used to Treat Children with Invasive Candidiasis, Including Candidemia (PROTOCOL A8851008) Mazade
(Expanded access CMX001) A Multicenter, Open-label Study of CMX001 Treatment of Serious Diseases or Conditions Caused by dsDNA Viruses Mazade
Emergency Use of Human Pythium Immunotherapy Murphey
Safety and Efficacy of Varicella Zoster Immune Globulin (Human) (VariZIG) in Patients At-Risk of Varicella Infection-Expanded Access Protocol Murphey
Efficacy of Carboplatin Administered Concomitantly with Radiation and Isoretinoin as a Pro-Apoptotic Agent in Other Than Average Risk Medullablastoma/PNET ACNS0332 Murray
Patient Care Evaluation Study of Institutional Brain Tumors Murray
A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children <36 months old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy without Methotrexate ACNS0334 Murray
TOPNOC 001-08: A Phase 2 Study of Valproic Acid and Radiation, followed by Maintenance Valproic Acid and Bevacizumab in Children with Newly Diagnosed High-Grade Gliomas or Brainstem Gliomas Murray
Treatment of Atypical Teratoid/Rhabdoid Tumors (AT/RT) of the Central Nervous System with Surgery, Intensive Chemotherapy, and 3-D Conformal Radiation ACNS0333 Murray
Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma Ages 1 to 21 Years ACNS0831 Murray
H6650, Texas Children's Cancer Center and Hematology Service Tissue Bank Murray
Temozolomide with Irinotecan versus Temozolomide, Irinotecan plus Bevacizumab (NSC# 704865, BB-IND# 7921) for Recurrent/Refractory Medulloblastoma/CNS PNET of Childhood, A COG

Randomized Phase II Screening Trial
Murray
A Randomized Phase II/III Study of Vorinostat (IND# 71976) and Local Irradiation OR Temozolomide and Local Irradiation OR Bevacizumab (IND# 7921) and Local Irradiation Followed by Maintenance Bevacizumab and Temozolomide in Children with Newly Diagnosed High-Grade Gliomas Murray
A Study Evaluating Limited Target Volume Boost Irradiation and Reduced Dose Craniospinal Radiotherapy (18.00Gy) and Chemotherapy in Children with Newly Diagnosed Standard Risk Medulloblastoma: A Phase III Double Randomized Trial ACNS0331 Murray
A COG Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens-COG ACNS02B3 Murray
Effects of 100% whey, partially hudrolyzed infant formula with probiotics on signs and symptems of "colic". Natterer
Registry for Neonatal Encephalopathy Nedrelow
(Ntrainer) Randomized Control Trial of Patterned Oral Somatosensory Entrainment Stimulation Program (NTrainer System®) for Shortening Time to Full Oral Feeding Nedrelow
(INOmax & BPD in preterms) Inhaled nitric oxide for the prevention of bronchopulmonary dysplasia (BPD) in preterm infants requiring mechanical ventilation or positive pressure support on days 5 to 14 after birth. Nedrelow
Evaluation of Factors Associated with Mortality in Neonates Nedrelow
Helping Children Understand the Meaning of Genetic Testing Newcomb
Health Disparities in Children with Asthma in North Texas Newcomb
Perceived Understanding, Use, and Importance of Genetic and Genomic Competencies by Nurses in Practice Newcomb
(C0168Z02 PEDIBD Registry) A Multicenter, Prospective, Long-term, Observational Registry of Pediatric Patients with Inflammatory Bowel Disease. Protocol No. C0168Z02 PIBD Site Agreement Ogunmola 8746 Ogunmola
Ultrasound Guided Supraclavicular Approach for Central Venous Catheter Insertion in Children Olarte-Motta
Gene discoveries in subjects with Crohn's Disease of African Descent Osuntokun
STAFF RESILIENCE IN THE PEDIATRIC INTENSIVE CARE UNIT (PICU):

SURVEY OF STAFF MEMBERS
Parrott
Safety Attitudes Questionnaire (SAQ) Patterson
North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)

Pena
Comprehensive Epilepsy Center Surgical Database Project Perry
An Evaluation of the Use of Clobazam for the Treatment of Refractory Pediatric Epilepsy Perry
(#P261-401) A Phase 3 Randomized, Double-Blind, Placebo-Controlled Cross-Over Study of the Safety and Efficacy of Intranasal Midazolam in the Outpatient Treatment of Subjects with Seizure Clusters. Protocol Number P261-401, entitled, "A Randomized, Double-Blind, Placebo-Controlled Study of the Safety and Efficacy of Intranasal Midazolam in the Outpatient Treatment of Subjects with Seizure Clusters" Perry
Reducing Catheter Associated Blood Stream Infections Initiative Petersen
NACHARI study on Ventilator Associated Pneumonia "VAPOR" Promes
A Pharmacokinetic/Pharmacodynamic and Safety Evaluation of Investigational Intravenous Peramivir in Children with Influenza Disease (DMID Protocol Number: 09-0064; BioCryst Protocol Number: BCX1812-205; Version 2.0 dated 02 December 2010) Rios
RESIST NAÏVE, Randomised Study of First Time Immunotolerance Induction in Patients with Severe Type A Haemophilia with Inhibitor at High Risk of Failure: Comparison of Induction of Immune Tolerance with FVIII Concentrates with or without Von Willebrand Factor Sanders
ReSiSTexp, Immune Tolerance Induction Study in Patients with Severe Type A Haemophilia with Inhibitor After Failure of a Previous Induction of Immune Tolerance with FVIII Concentrates without von Willebrand Factor Sanders
The American Thrombosis and Hemostasis Network (ATHN) National Web Tracker Sanders
A-LONG: An Open-Label, Multicenter Evaluation of the Safety, Pharmacokinetics, and Efficacy of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in the Prevention and Treatment of Bleeding in Previously Treated Subjects with Severe Hemophilia A Sanders
Infusion Administration Observation Survey Sanders
Epidemiology and Treatment of Circulating Anticoagulants in Patients with Hemophilia and von Willebrand Disease-The HTRS Registry Sanders
A Phase 3, Multi-center, Multinational, Randomized, Double-blind, Placebo-controlled study to Evaluate the Efficacy and Safety of MP-376 (Levofloxacin Inhalation Solution; Aeroquin™) in Stable Cystic Fibrosis Patients Schultz
A Phase 3, Open-Label, Randomized Trial to Evaluate the Safety and Efficacy of MP-376 Inhalation Solution (Aeroquin) Versus Tobramycin Inhalation Solution (TIS) in Stable Cystic Fibrosis Patients. Schultz
Early MRSA therapy in CF – culture based vs. observant therapy (treat or observe).

(STAR-too – STaph Aureus Resistance – treat or observe)
Schultz
(CCISC Registry) Comparison Between Surgical versus Balloon Angioplasty versus Intravascular Stent Placement for Recurrent or Native Coarctation of the Aorta Schutte
Humanitarian Device Exemption (H080002) - Medtronic Melody® Transcatheter Pulmonary Valve (Model PB10) and Medtronic Ensemble® Transcatheter Valve Delivery System (NU10) (HUD#07-0180) Schutte
A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Efficacy and Safety Study of Ezetimibe Monotherapy in Children (Ages 6 to 10 Years) with Primary Hypercholesterolemia (Heterozygous Familial and Nonfamilial) (Protocol No. P05522) Siu
Evaluation of Post-Baccalaureate Nurse Residency Smith
Sleep Quality and Sleep Behaviors in Pediatric Night Nurses: A Pilot Study Smith
(IGFD Registry) Increlex (Increlex®(mecasermin [rDNA origin] injection)Growth Forum Database - IGFD Registry: A Patient Registry for Monitoring Long-term Safety and Efficacy of Increlex® Steelman
Chart review of patients whom have had a Histrelin implant Thornton
Hyperinsulinism Center Registry for Research and Quality Data Collection Thornton
A Multicenter Pilot Study of Pediatric Patients in the NICU, PICU and Other Intensive Care Units Treated with Octreotide Thornton
(KIGS) Kabi International Growth Study Thornton
The Genetics and Neuroendocrinology of Short Stature International Study (GENESIS): Data Collection Thornton
The ANSWER Program: American Norditropin Studies: Web Enabled Research; An Observational Study (Registry) Assessing Treatment Outcomes and Safety for Children and Adults who are Prescribed Norditropin® (Human Growth Hormone)

Study ID: HGH-2149



Thornton
A Multi-center, Prospective, Open-label, Clinical Trial to Assess the Safety and the Efficacy of a New Intravenous Immune Globlulin (IGIV3I Grifols 10%) in Patients with Idiopathic (Immune) Thrombocytopenic Purpura IG0601 Torres
Efficacy and Safety of Fibrinogen Concentrate (Human) for On-Demand Treatment of Acute Bleeding in Subjects with Congenital Fibrinogen Deficiency BI3023_3001 Torres
A Three-month Prospective Open Label study of Therapy with FRAGMIN (Dalteparin Sodium Injection) in Children with Malignancies and Venous Thromboembolism Torres
Warfarin Pharmacogenetics in Pediatric Patients: Development and Testing of a Pharmacogenetic-Based Dosing Algorithm Torres
F7HAEM-3521, Treatment of Glanzmann's Thrombasthenia. A Prospective Observational Registry. Torres
CV185079, BMS-562247, Multiple-Dose Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Apixaban in Pediatric Subjects with an Indwelling Central Venous Catheter Torres
Glanzmann's Thrombasthenia Review: The Cook Children's Experience Torres
400701, Ceprotin Treatment Registry Torres
Prospective Multi-Center Evaluation of the Duration of Therapy for Thrombosis in Children (The "Kids-DOTT" Trial) Torres
ThromboEmbolism Registry Torres
Targeted Kinase Therapy in Pediatric Leukemia; A Case Series Trinkman

Cook Children's research and quality improvement:


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