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Spotlight on Neuroscience Research

Arcuate Newsletter

Research is an integral part to any successful program and the Jane and John Justin Neurosciences Center continues to be a leader in many areas. We currently participate in 28 sponsored and investigator-initiated trials. These bring innovative treatments to the children of our region which otherwise would not be available, including cannabidiol and fenfluramine for intractable epilepsy and triheptanoin for Glut-1 deficiency.

Collaboration is key

National and international collaboration is vital to improving neurosciences research and outcomes for our patients. Cook Children's Neurosciences led the development of the international Deep Brain Stimulator Registry to collect data on this innovative procedure. We also were the first Texas hospital to join the Pediatric Epilepsy Research Consortium and have contributed numerous cases to the national iMRI Neurosurgery Database. Additional collaborations are ongoing with Cincinnati Children's, University of Washington, Dell Children's and Nationwide Children's.

DID YOU KNOW?
The research of Warren Marks, M.D. has been cited over 525 times.

Cook Children's Neurosciences researchers served as primary or co-authors on 11 publications in 2016.

Daniel, C., & Perry, M. S. (2016). Ictal coprolalia: A case report and review of ictal speech as a localizing feature in epilepsy. Pediatric Neurology, 57, 88-90. doi:10.1016/j.pediatrneurol.2015.11.013

Fahrner, J. A., Liu, R., Perry, M. S., Klein, J., & Chan, D. C. (2016). A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy. American Journal of Medical Genetics. Part A, 170(8), 2002-2011. doi:10.1002/ajmg.a.37721

Hodges, S. L., Gabriel, M. T., & Perry, M. S. (2016). Neuropsychological findings associated with panayiotopoulos syndrome in three children. Epilepsy & Behavior : E&B, 54, 158-162. doi:10.1016/j.yebeh.2015.11.012

Knupp, K. G., Leister, E., Coryell, J., Nickels, K. C., Ryan, N., Juarez-Colunga, E., Gaillard, W. D., Mytinger, J. R., Berg, A. T., Millichap, J., Nordli, D. R.,Jr, Joshi, S., Shellhaas, R. A., Loddenkemper, T., Dlugos, D., Wirrell, E., Sullivan, J., Hartman, A. L., Kossoff, E. H., Grinspan, Z. M., Hamikawa, L., Brooks-Kayal, A., Stack, C., Brown, L., Keator, C., Mitchell, W. G., Jansen, L. A., Kumar, S., Kumar, G., Theile, E., Chu, C., Kelley, S. A., Yozawitz, E., Joshi, C. N., Valencia, I., Wusthoff, C. J., Novotny, E. J., Saneto, R. P., Hussain, S. A., & Pediatric Epilepsy Research Consortium. (2016). Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia, 57(11), 1834-1842. doi:10.1111/epi.13557

Koy, A., Lin, J. P., Sanger, T. D., Marks, W. A., Mink, J. W., & Timmermann, L. (2016). Advances in management of movement disorders in children. The Lancet.Neurology, 15(7), 719-735. doi:10.1016/S1474-4422(16)00132-0

Marks, W., Bailey, L., & Sanger, T. D. (2016). PEDiDBS: The pediatric international deep brain stimulation registry project. European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society, doi:S1090-3798(16)30081-2

Millichap, J. J., Miceli, F., De Maria, M., Keator, C., Joshi, N., Tran, B., Soldovieri, M. V., Ambrosino, P., Shashi, V., Mikati, M. A., Cooper, E. C., & Taglialatela, M. (2017). Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. Epilepsia, 58(1), e10-e15. doi:10.1111/epi.13601

Perry, M. S. (2016). Are we winning the battle but losing the war? Sequelae of surviving epilepsy. Epilepsy Currents, 16(3), 139-140. doi:10.5698/1535-7511-16.3.139

Perry, M. S. (2016). Genetic testing in epileptic encephalopathy: Rosetta stone or just an expensive rock? Epilepsy Currents, 16(1), 12-13. doi:10.5698/1535-7597-16.1.12

Perry, M. S. (2016). Meaningful results in a jiffy - A PERC of multicenter collaborations. Epilepsy Currents, 16(5), 299-301. doi:10.5698/1535-7511-16.5.299

Steinfeld, H., Cho, M. T., Retterer, K., Person, R., Schaefer, G. B., Danylchuk, N., Malik, S., Wechsler, S. B., Wheeler, P. G., van Gassen, K. L., Terhal, P. A., Verhoeven, V. J., van Slegtenhorst, M. A., Monaghan, K. G., Henderson, L. B., & Chung, W. K. (2016). Mutations in HIVEP2 are associated with developmental delay, intellectual disability, and dysmorphic features. Neurogenetics, 17(3), 159-164. doi:10.1007/s10048-016-0479-z