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Histiocytic Disorders Program

Whether your child is diagnosed with a well-known condition or a rare one, you and your family deserve only the best care! That is why, at Cook Children's, we have created a brave army of doctors, nurses, research analysts and pharmacists who are dedicated to care for your child, even when the diagnosis is something as uncommon as Langerhans cell histiocytosis (LCH).

The Cook Children's Histiocytic Disorders Program is experienced in treating a wide range of histiocytic disorders including Langerhans cell histiocytosis (LCH) and hemophagocytic lymphohistiocytosis (HLH) and offers the most comprehensive and highest level of care in North Texas.

Why Cook Children's

Our expertise and collaborations with ongoing clinical trials and innovative approaches rely on a team of specialists from Hematology and Oncology as well as Interventional Radiology, Orthopedics, Radiology, Endocrinology and Neurosurgery, when appropriate.

Our multidisciplinary clinical team remains committed to providing the highest level of care for this rare group of disorders. Accordingly we have successfully partnered with Texas Children's Hospital and other leading institutions in offering multiple treatment and clinical trial options to patients with newly diagnosed LCH. Because of our expertise, we also serve as a referral center for patients outside of our region.

On the other hand, for patients who have sustained relapse, we have embarked upon a gene testing based approach to identify patients with BRAF mutation, a condition that can be targeted by non- chemotherapeutic approaches.

Last but not least, a select group of patients will benefit from detailed genomic testing of the entire tumor tissue to identify specific mutations that can be targeted by particular drugs.

Langerhans cell histiocytosis (LCH)

What is LCH?

What drives LCH?

What are the signs and symptoms?

Testing and diagnosis?

How is it treated?

What is the long term outlook?

Our LCH team

Hemophagocytic lymphohistiocytosis (HLH)

What is HLH?

What causes HLH?

What are the signs and symptoms?

Testing and diagnosis?

How is it treated?

What is the long term outlook?

Our HLH team

We are here to help.

Have questions or need to make a referral? We can help. If you would like to speak to one of our staff, please call our offices at 682-885-4007.